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1st February 2012

Ulcer drugs linked to hip fractures

Scientists have found a connection between ulcer drugs and hip fractures in women, particularly in those that smoke.

Research published in the British Medical Journal [BMJ 2012;344:e372] suggests that proton pump inhibitors (PPIs) used to treat heartburn, reflux and ulcers can increase the risk of hip fractures in women in later life.

The study led by a team at the Massachusetts General Hospital in Boston monitored 8,000 women aged between 30 and 55. Researchers found that smokers or ex-smokers taking PPIs had a 50% increased risk of hip fractures in later life, compared with women not taking the medication.

Anything that increases the risk of hip fracture is a concern

Professor of Orthopaedic Trauma Surgery at Nottingham University and Chair of the British Orthopaedic Association Trauma Group, Chris Moran, said: "Anything that increases the risk of hip fracture is a concern to orthopaedic surgeons who treat these fractures and it is important that GPs who prescribe PPIs are aware that these drugs may increase the risk of hip fracture.

"However, we must recognise that PPIs are used to prevent and treat serious conditions, such as stomach ulcers.

"Doctors treating these conditions will balance the risks of the ulcer against longer term risks, such as hip fracture."

Madeleine Pinschof, a solicitor at Thompsons Solicitors’ Clinical Negligence Unit said: “Hip fractures often result in a disability, persistent pain or limited mobility. The risk that PPIs increases the chances of such an injury needs to be taken into account, particularly in women with a smoking history.”

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